Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

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Authors	Koizumi, Ryo Graduate School of Engineering, Tottori University Azuma, Kazuo Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN Izawa, Hironori Graduate School of Engineering, Tottori University Researchers DB KAKEN Morimoto, Minoru Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University Researchers DB KAKEN Ochi, Kosuke Department of Veterinary Clinical Medicine, Tottori University Tsuka, Takeshi Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN Imagawa, Tomohiro Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN Osaki, Tomohiro Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN Ito, Norihiko Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN Okamoto, Yoshiharu Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN Saimoto, Hiroyuki Graduate School of Engineering, Tottori University Researchers DB KAKEN Ifuku, Shinsuke Graduate School of Engineering, Tottori University Researchers DB KAKEN
Keywords	surface deacetylated chitin nanofiber chitosan mucositis 5-fluorouracil apoptosis
Abstract	This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
Publisher	MDPI
Content Type	Journal Article
Link	https://www.mdpi.com/1422-0067/18/2/279
ISSN	14220067
NCID	AA12038549
Journal Title	International Journal of Molecular Sciences
Volume	18
Issue	2
Start Page	279
Published Date	2017-01-27
Publisher-DOI	10.3390/ijms18020279
Text Version	Publisher
Rights	© 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citation	KOIZUMI, Ryo, et al. Oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fluorouracil-induced intestinal mucositis in mice. International journal of molecular sciences, 2017, 18.2: 279. https://doi.org/10.3390/ijms18020279
Department	Faculty of Engineering/Graduate School of Engineering
Language	English