| File | |
| Authors |
Okuno, Keisuke
Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Researchers DB
Yoneda, Naohiro
Department of Pediatrics, Matsue City Hospital,
Nishimura, Rei
Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Researchers DB
Sano, Hiroshi
Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Ueyama, Jun-ichi
Department of Pediatrics, Matsue City Hospital
Komatsu, Hiroaki
Department of Obstetrics and Gynecology, Japanese Red Cross Yamaguchi Hospital
Harada, Tasuku
Division of Reproductive-Perinatal Medicine and Gynecologic Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Researchers DB
KAKEN
Kuwamoto, Satoshi
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine
Researchers DB
KAKEN
Horie, Yasushi
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine
Researchers DB
KAKEN
Kanzaki, Susumu
Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Researchers DB
KAKEN
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| Keywords | delayed puberty
interleukin-6
juvenile granulosa cell tumor
prolonged fever
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| Abstract | Juvenile granulosa cell tumor (JGCT), classified as a sex cord-stromal tumor, is a rare neoplasm. This is an instructive case report of JGCT accompanied by augmented interleukin (IL)-6 secretion. A 13-year-old girl with prolonged fever and delayed puberty was diagnosed with JGCT of the left ovary based on an imaging study and pathological investigation. Although it was not clear whether IL-6 was secreted from the tumor cells, her serum level of IL-6 was very high. After tumorectomy, the patient’s symptoms immediately disappeared, her IL-6 level decreased, and she entered puberty. Therefore, augmented IL-6 secretion production induced by tumors should be considered a potential cause of prolonged fever and/or delayed puberty.
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| Publisher | Tottori University Medical Press
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| Content Type |
Journal Article
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| Link | |
| ISSN | 0513-5710
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| EISSN | 1346-8049
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| NCID | AA00892882
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| Journal Title | Yonago Acta Medica
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| Current Journal Title |
Yonago Acta Medica
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| Volume | 62
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| Issue | 3
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| Start Page | 263
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| End Page | 267
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| Journal Section | Patient Report
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| Published Date | 2019-9-13
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| Publisher-DOI | |
| Text Version |
Publisher
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| Rights | 注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
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| Citation | Okuno K, Yoneda N, Nishimura R, Sano H, Ueyama J-i, Komatsu H, et al. Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty. Yonago Acta Medica. 2019;62:263-267.
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| Department |
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
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| Language |
English
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