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Authors
Okura, Tsuyoshi Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Ueta, Etsuko School of Health Science, Tottori University Faculty of Medicine
Nakamura, Risa Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Fujioka, Yohei Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Sumi, Keisuke Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB
Matsumoto, Kazuhisa Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Shoji, Kyoko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Matsuzawa, Kazuhiko Department of Regional Medicine, Tottori University Faculty of Medicine Researchers DB
Izawa, Shoichiro Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Nomi, Yuri Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences
Mihara, Hitomi Department of Food and Nutrition, Toita Women’s College
Otsuka, Yuzuru Department of Food and Nutrition, Toita Women’s College KAKEN
Kato, Masahiko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Taniguchi, Shin-ichi Department of Regional Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Yamamoto, Kazuhiro Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Abstract
Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes.
Publisher
Hindawi
Content Type
Journal Article
Link
ISSN
23146745
EISSN
23146753
Journal Title
JOURNAL OF DIABETES RESEARCH
Current Journal Title
JOURNAL OF DIABETES RESEARCH
Volume
2017
Published Date
2017
Publisher-DOI
Text Version
Publisher
Rights
Copyright © 2017 Tsuyoshi Okura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation
Okura Tsuyoshi, Ueta Etsuko, Nakamura Risa, et al. High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report. JOURNAL OF DIABETES RESEARCH. 2017. 2017. doi:10.1155/2017/5139750
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Web of Science Key ut
WOS:000403284600001