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Authors |
Colak, Dilek
Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research
Mori, Tetsuji
Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research
Researchers DB
KAKEN
S. Brill, Monika
Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research / Physiological Genomics, University of Munich
Pfeifer, Alexander
Institute for Pharmacology and Toxicology, University of Bonn
Falk, Sven
Institute of Anatomy, University of Zurich
Deng, Chuxia
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Monteiro, Rui
Developmental Biology, Hubrecht Institute
Mummery, Christine
Developmental Biology, Hubrecht Institute
Sommer, Lukas
Institute of Anatomy, University of Zurich
Götz, Magdalena
Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research / Physiological Genomics, University of Munich
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Keywords | neural stem cells
Olig2
Dlx2
neurogenesis
oligodendrocytes
transplantation
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Abstract | In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. Transplantation experiments further verified the cell-autonomous nature of this phenotype. Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis.
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Publisher | Society for Neuroscience
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Content Type |
Journal Article
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Link | |
ISSN | 02706474
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NCID | AA10620404
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Journal Title | The Journal of Neuroscience
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Current Journal Title |
The Journal of Neuroscience
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Volume | 28
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Issue | 2
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Start Page | 434
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End Page | 445
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Journal Section | Development/Plasticity/Repair
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Published Date | 2008-01-09
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Publisher-DOI | |
Text Version |
Publisher
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Rights | Copyright © 2008 Society for Neuroscience
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Citation | Colak, Dilek, et al. "Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells." Journal of Neuroscience 28.2 (2008): 434-446.
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Department |
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
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Language |
English
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