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内因性NLRP3インフラマソーム阻害剤であるベータヒドロキシ酪酸の前頭前野への注入は、げっ歯類のうつ病モデルに抗うつ薬のような効果を示す
Authors
Kajitani, Naofumi Division of Neuropsychiatry, Department of Brain and Neuroscience, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Content Type
Thesis or Dissertation
Link
Publisher-DOI
Text Version
ETD
Rights
© 2020 The Authors.Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology.
Citation
Naofumi Kajitani,Masaaki Iwata,Akihiko Miura,Kyohei Tsunetomi,Takehiko Yamanashi,Ryoichi Matsuo,Tsuyoshi Nishiguchi,Saki Fukuda,Mayu Nagata,Midori Shibushita,Takahira Yamauchi,Shenghong Pu,Yukihiko Shirayama,Ken Watanabe,Koichi Kaneko. Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression. Neuropsychopaharmacology reports. 2020, , . https://doi.org/10.1002/npr2.12099.
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Grant ID
甲第935号
Granted Date
2020/3/31
Degree Name
博士(医学)
Grantor
鳥取大学