ijms18(2)_279.pdf 4.11 MB
Koizumi, Ryo Graduate School of Engineering, Tottori University
Morimoto, Minoru Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University Researchers DB KAKEN
Ochi, Kosuke Department of Veterinary Clinical Medicine, Tottori University
Imagawa, Tomohiro Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN
Okamoto, Yoshiharu Department of Veterinary Clinical Medicine, Tottori University Researchers DB KAKEN
surface deacetylated chitin nanofiber
This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
International Journal of Molecular Sciences
© 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
KOIZUMI, Ryo, et al. Oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fluorouracil-induced intestinal mucositis in mice. International journal of molecular sciences, 2017, 18.2: 279. https://doi.org/10.3390/ijms18020279
Faculty of Engineering/Graduate School of Engineering