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Authors
Matsunaga, Tomoyuki Department of Digestive Surgery, Osaka International Cancer Institute / Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Miyata, Hiroshi Department of Digestive Surgery, Osaka International Cancer Institute
Sugimura, Keijiro Department of Digestive Surgery, Osaka International Cancer Institute
Motoori, Masaaki Department of Surgery, Osaka General Medical Center
Asukai, Kei Department of Digestive Surgery, Osaka International Cancer Institute
Yanagimoto, Yoshitomo Department of Digestive Surgery, Osaka International Cancer Institute
Yamamoto, Kazuyoshi Department of Digestive Surgery, Osaka International Cancer Institute
Akita, Hirofumi Department of Digestive Surgery, Osaka International Cancer Institute
Nishimura, Junichi Department of Digestive Surgery, Osaka International Cancer Institute
Wada, Hiroshi Department of Digestive Surgery, Osaka International Cancer Institute
Takahashi, Hidenori Department of Digestive Surgery, Osaka International Cancer Institute
Yasui, Masayoshi Department of Digestive Surgery, Osaka International Cancer Institute
Omori, Takeshi Department of Digestive Surgery, Osaka International Cancer Institute
Ohue, Masayuki Department of Digestive Surgery, Osaka International Cancer Institute
Fujiwara, Yoshiyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Yano, Masahiko Department of Digestive Surgery, Osaka International Cancer Institute
Keywords
C-reactive protein-to-prealbumin ratio
esophageal cancer
esophagectomy
inflammatory marker
prognosis
Abstract
Background: The prognostic value of combination of C-reactive protein and prealbumin (CRP/PAlb) in esophageal cancer remains unclear.

Methods: We enrolled 167 esophageal cancer patients who underwent curative esophagectomy. Univariate and multivariate analyses were performed to determine the prognostic significance of various markers, including CRP-to-albumin (CRP/Alb) ratio, modified Glasgow prognostic score, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index.

Results: Receiver operating characteristic analysis revealed the optimal cut-off value of each inflammatory factor, and CRP/PAlb ratio had the greatest discriminative power in predicting recurrence-free survival (RFS) among the examined measures (AUC 0.668). The 5-year overall survival and RFS rates were significantly lower in patients with high CRP/PAlb ratio than in those with low CRP/PAlb ratio (P < 0.001, P = 0.001, respectively). In the univariate analysis, RFS was significantly worse in patients with low BMI, T2 or deeper tumor invasion, positive lymph node metastasis, positive venous invasion, high CRP/PAlb ratio, high CRP/Alb ratio, high NLR, and high LMR. Multivariate analysis revealed that CRP/PAlb, but not CRP/Alb, was an independent prognostic factor along with lymph node metastasis.

Conclusion: CRP/PAlb ratio was useful for predicting the prognosis of esophageal cancer patients.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
63
Issue
1
Start Page
8
End Page
19
Original Article
Published Date
2020-02-20
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Tomoyuki Matsunaga, Hiroshi Miyata, Keijiro Sugimura, Masaaki Motoori, Kei Asukai, Yoshitomo Yanagimoto, Kazuyoshi Yamamoto, Hirofumi Akita, Junichi Nishimura, Hiroshi Wada, Hidenori Takahashi, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano, Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer, Yonago Acta Medica, 2020, Volume 63, Issue 1, Pages 8-19, Released February 20, 2020
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English