File
Authors
Morimoto, Masaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN
Honjo, Soichiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Sakamoto, Teruhisa Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Yagyu, Takuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Uchinaka, Ei Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Hanaki, Takehiko Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Watanabe, Joji Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Matsunaga, Tomoyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Yamamoto, Manabu Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Fukumoto, Yoji Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Tokuyasu, Naruo Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Fujiwara, Yoshiyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Keywords
CRP
pancreatic cancer
platelet
prognosis
Abstract
Background: C-reactive protein (CRP) levels reflect ongoing inflammation and/or tissue damage, and studies suggest that platelets play a role in tumor invasion and metastasis. P-CRP is defined as the multiplied product of serum CRP and platelet levels. Here the prognostic value of pre- and post-operative P-CRP levels in pancreatic cancer (PC) patients was assessed.

Methods: This retrospective study used data from 107 consecutive PC patients who had undergone either pancreaticoduodenectomy or distal pancreatectomy. Clinicopathological parameters and pre/post-operative laboratory data derived from patient records were used for analyses. P-CRP was defined as the product of peripheral thrombocyte count (/uL) × serum CRP level (mg/dL) divided by 104; the optimal P-CRP cut-off value was defined using receiver operating characteristic curves.

Results: PC patients were classified as either P-CRPLow (< 1.782; n = 49) or P-CRPHigh (≥ 1.782; n = 58), based on the cut-off value of 1.782. Univariate analysis revealed that performance status, clinical stage, pathological T and N stages, P-CRP, and carbohydrate antigen 19-9 (CA19-9) significantly affected overall survival (OS). Multivariate analysis revealed that independent risk factors for OS were pathological N stage, P-CRP, and CA19-9. Additionally, 103 PC patients for whom postoperative data were available were classified into four groups (P-CRPLow-Down, P-CRPLow-Up, P-CRPHigh-Down and P-CRPHigh-Up), based on preoperative P-CRP and postoperative trend of P-CRP, and we found that prognosis, in terms of OS, was significantly different among these groups (P = 0.012).

Conclusion: Pre- and post-operative P-CRP values are a potential predictor of prognosis in PC patients.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
63
Issue
1
Start Page
70
End Page
78
Original Article
Published Date
2020-02-20
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Takuki Yagyu, Ei Uchinaka, Takehiko Hanaki, Joji Watanabe, Tomoyuki Matsunaga, Manabu Yamamoto, Yoji Fukumoto, Naruo Tokuyasu, Yoshiyuki Fujiwara, Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients, Yonago Acta Medica, 2020, Volume 63, Issue 1, Pages 70-78, Released February 20, 2020
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English