joc85(3)_1668.pdf 2.5 MB
Matsuura, Kazunori Tottori University Researchers DB KAKEN
Ota, Junpei Tottori University
Fujita, Seiya Tottori University
Shiomi, Yuriko Tottori University
Inaba, Hiroshi Tottori University Researchers DB KAKEN
Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein. The β-annulus-S-peptide was synthesized by native chemical ligation of β-annulus-SBz peptide with Cys-containing S-peptide that self-assembled into artificial virus-like capsids of approximately 47 nm in size. Reconstruction of RNase S on the artificial virus-like capsids afforded spherical assembly attached small spheres on the surface, which retained ribonuclease activity.
American Chemical Society
JOURNAL OF ORGANIC CHEMISTRY
(C) 2021 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
Matsuura Kazunori, Ota Junpei, Fujita Seiya, et al. Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly. JOURNAL OF ORGANIC CHEMISTRY. 2020. 85(3). 1668-1673. doi:10.1021/acs.joc.9b02295
Faculty of Engineering/Graduate School of Engineering
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