File
Authors
Ninkovic, Jovica Institute for Stem Cell Research, Gesellschaft fu¨r Strahlenforschung-National Research Institute for Environment and Health
Mori, Tetsuji Institute for Stem Cell Research, Gesellschaft fu¨r Strahlenforschung-National Research Institute for Environment and Health Researchers DB KAKEN
Götz, Magdalena Physiological Genomics, University of Munich
Keywords
granule cells
periglomerular neurons
dentate gyrus
olfactory bulb
neuron integration
neural network
Abstract
Adult neurogenesis is restricted to two distinct areas of the mammalian brain: the olfactory bulb (OB) and the dentate gyrus (DG). Despite its spatial restriction, adult neurogenesis is of crucial importance for sensory processing and learning and memory. Although it has been shown that tens of thousands of new neurons arrive in the OB and DG every day with about half of them surviving after integration, the total contribution of adult neurogenesis to the pre-existing network remains mostly unknown. This is because of previous approaches labeling only a small proportion of adult-generated neurons. Here, we used genetic fate mapping to follow the majority of adult-generated neurons over long periods. Our data demonstrate two distinct modes of neuron addition to the pre-existing network. In the glomerular layer of the OB, there is a constant net addition of adult-generated neurons reaching a third of the total neuronal population within 9 months. In contrast, adult neurogenesis contributes to only a minor fraction of the entire neuronal network in the granular cell layer of the OB and the DG. Although the fraction of adult generated neurons can be further increased by an enriched environment, it still remains a minority of the neuronal network in the DG. Thus, neuron addition is distinct and tightly regulated in the neuronal networks that incorporate new neurons life long.
Publisher
Society for Neuroscience
Content Type
Journal Article
Link
ISSN
02706474
NCID
AA10620404
Journal Title
The Journal of Neuroscience
Current Journal Title
The Journal of Neuroscience
Volume
27
Issue
40
Start Page
10906
End Page
10911
Brief Communications
Published Date
2007-10-03
Publisher-DOI
Text Version
Publisher
Rights
Copyright ©2007 Society for Neuroscience
Citation
Ninkovic, Jovica, Tetsuji Mori, and Magdalena Götz. "Distinct modes of neuron addition in adult mouse neurogenesis." Journal of Neuroscience 27.40 (2007): 10906-10911.
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English