File
Authors
Keywords
Antarctica
cytokine
high altitude; interleukin-6
mountain sickness
Abstract
We evaluated the impact of the extreme environmental conditions at high altitudes in Antarctica on health from the viewpoint of cytokines. The subjects were 7 men who joined an inland research party participating in the 40th Japanese Antarctic Research Expedition. They underwent serial hematological examinations during the expedition for over 100 days at high altitudes (the highest point was 3810 m). The serum concentration of erythropoietin (EPO) increased promptly, indicating its usefulness for altitude adaptation. The serum concentration of interleukin-6 (IL-6) increased at high altitudes, and showed 2 peaks. Changes in IL-6 levels did not correlate with arterial oxygen tension, serum C-reactive protein or EPO levels. Some psychological stress and various factors may be related to IL-6 levels. Since the subject who suffered bone fractures had a very high concentration of IL-6 and his symptoms of mountain sickness were severer than the others, elevation of IL-6 may be related with mountain sickness. All subjects remained in relatively good health for 3 months. It is thought that the human body can protect itself against extreme surroundings in Antarctica.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
46
Issue
2
Start Page
29
End Page
34
Published Date
2003-06
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 2003, 46(2), 29-34
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English