File
Authors
Okuno, Keisuke Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Yoneda, Naohiro Department of Pediatrics, Matsue City Hospital,
Nishimura, Rei Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Sano, Hiroshi Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Ueyama, Jun-ichi Department of Pediatrics, Matsue City Hospital
Komatsu, Hiroaki Department of Obstetrics and Gynecology, Japanese Red Cross Yamaguchi Hospital
Harada, Tasuku Division of Reproductive-Perinatal Medicine and Gynecologic Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Kuwamoto, Satoshi Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Horie, Yasushi Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Kanzaki, Susumu Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Keywords
delayed puberty
interleukin-6
juvenile granulosa cell tumor
prolonged fever
Abstract
Juvenile granulosa cell tumor (JGCT), classified as a sex cord-stromal tumor, is a rare neoplasm. This is an instructive case report of JGCT accompanied by augmented interleukin (IL)-6 secretion. A 13-year-old girl with prolonged fever and delayed puberty was diagnosed with JGCT of the left ovary based on an imaging study and pathological investigation. Although it was not clear whether IL-6 was secreted from the tumor cells, her serum level of IL-6 was very high. After tumorectomy, the patient’s symptoms immediately disappeared, her IL-6 level decreased, and she entered puberty. Therefore, augmented IL-6 secretion production induced by tumors should be considered a potential cause of prolonged fever and/or delayed puberty.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN・ISBN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
62
Issue
3
Start Page
263
End Page
267
Patient Report
Published Date
2019-09-13
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Okuno K, Yoneda N, Nishimura R, Sano H, Ueyama J-i, Komatsu H, et al. Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty. Yonago Acta Medica. 2019;62:263-267.
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English