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Authors |
Ogawa, Kenjirou
Organization for Promotion of Tenure Track, University of Miyazaki
Ishii, Ayumi
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University
Shindo, Aimi
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
Hongo, Kunihiro
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University
Researchers DB
KAKEN
Mizobata, Tomohiro
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University
Researchers DB
KAKEN
Sogon, Tetsuya
R&D Department,Wakasa Seikatsu Co. Ltd.
Kawata, Yasushi
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University
Researchers DB
KAKEN
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Keywords | spearmint
rosmarinic acid
polyphenol
amyloid fibril
amyloid beta
alpha-synuclein
Tau
dementia
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Abstract | Neurological dementias such as Alzheimer’s disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregates in order to prevent and/or delay the progression of dementia in these ailments. In this report, we investigated the effects of spearmint extract (SME) and rosmarinic acid (RA; the major component of SME) on the amyloid fibril formation reactions of αSyn, Aβ, and Tau proteins in vitro. SME or RA was added to soluble samples of each protein and the formation of fibrils was monitored by thioflavin T (ThioT) binding assays and transmission electron microscopy (TEM). We also evaluated whether preformed amyloid fibrils could be dissolved by the addition of RA. Our results reveal for the first time that SME and RA both suppress amyloid fibril formation, and that RA could disassemble preformed fibrils of αSyn, Aβ, and Tau into non-toxic species. Our results suggest that SME and RA may potentially suppress amyloid fibrils implicated in the progression of Alzheimer’s disease and Lewy body dementia in vivo, as well.
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Publisher | MDPI
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Content Type |
Journal Article
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EISSN | 20726643
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Journal Title | NUTRIENTS
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Volume | 12
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Issue | 11
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Published Date | 2020-11
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Text Version |
Publisher
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Rights | (C) 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Citation | Ogawa Kenjirou, Ishii Ayumi, Shindo Aimi, et al. Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia. NUTRIENTS. 2020. 12(11). doi:10.3390/nu12113480
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Department |
Faculty of Engineering/Graduate School of Engineering
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Language |
English
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Web of Science Key ut | WOS:000593882900001
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