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日本人の潰瘍性大腸炎患者におけるヒト白血球抗原と臨床的特徴の関連
Authors
Iwamoto, Taku
Keywords
HLA
inflammatory bowel disease
Japanese
ulcerative colitis
Abstract
【Background】 The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn’s disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC.
【Methods】 In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients. In addition, whether the HLA alleles are related to patient and clinical background characteristics was examined.
【Results】 Overall, 62.2%, and 66.7% of the 45 UC patients had HLA-B*52 and HLA-DRB1*15, respectively. These allele frequencies were significantly higher than in previously reported Japanese control persons (P < 0.0001). The frequencies of extraintestinal manifestations [odds ratio (OR) = 0.12, P = 0.039] and a history of colectomy (OR = 0.18, P = 0.046) were lower in HLA-B*52-positive UC patients than in HLA-B*52 negative UC patients. The white blood cell (WBC) count was significantly higher in HLA-DRB1*15-positive patients (9430 ± 4592/μL) than in HLA-DRB1*15-negative patients (6729 ± 2160/μL). Thus, HLA-B*52 and DRB1*15 appear to be associated with disease features and severity in Japanese UC patients.
【Conclusion】 These results indicate that HLA-B*52 and DRB1*15 are not only associated with overall UC susceptibility, but also with the clinical phenotypes in Japanese patients.
Content Type
Thesis or Dissertation
Link
Current Journal Title
Published Date
2018-03-01
Text Version
ETD
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。
Citation
This research was published by Yonago Acta Medica: Taku Iwamoto, Kazuo Yashima, Keiko Morio, Naoki Ueda, Yuichiro Ikebuchi, Koichiro Kawaguchi, Kenichi Harada and Hajime Isomoto. Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis. Yonago Acta Medica, 2018, 61, pp.27-32
Language
English
Grant ID
甲第881号
Granted Date
2018-03-01
Degree Name
博士(医学)
Grantor
鳥取大学