File
Authors
Kawashima, Fumiaki Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University
Saito, Kengo Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University
Kurata, Hirofumi Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University / Division of Child Neurology, Department of Brain and Neurosciences, Faculty of MedicineTottori University Researchers DB KAKEN
Maegaki, Yoshihiro Division of Child Neurology, Department of Brain and Neurosciences, Faculty of MedicineTottori University Researchers DB KAKEN
Mori, Tetsuji Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University Researchers DB KAKEN
Keywords
c-Jun
Immunohistochemistry
Development
Adult neurogenesis
Status epilepticus
Abstract
c-jun, a major component of AP-1 transcription factor, has a wide variety of functions. In the embryonic brain, c-jun mRNA is abundantly expressed in germinal layers around the ventricles. Although the subventricular zone (SVZ) of the adult brain is a derivative of embryonic germinal layers and contains neural precursor cells (NPCs), the c-jun expression pattern is not clear. To study the function of c-jun in adult neurogenesis, we analyzed c-jun expression in the adult SVZ by immunohistochemistry and compared it with that of the embryonic brain. We found that almost all proliferating embryonic NPCs expressed c-jun, but the number of c-jun immunopositive cells among proliferating adult NPCs was about half. In addition, c-jun was hardly expressed in post-mitotic migrating neurons in the embryonic brain, but the majority of c-jun immunopositive cells were tangentially migrating neuroblasts heading toward the olfactory bulb in the adult brain. In addition, status epilepticus is known to enhance the transient proliferation of adult NPCs, but the c-jun expression pattern was not significantly affected. These expression patterns suggest that c-jun has a pivotal role in the proliferation of embryonic NPCs, but it has also other roles in adult neurogenesis.
Publisher
Springer Berlin Heidelberg
Content Type
Journal Article
Link
ISSN・ISBN
09486143
NCID
AA11033302
Journal Title
Histochemistry and cell biology
Volume
147
Issue
6
Start Page
721
End Page
731
Original Paper
Published Date
2017-01-16
Publisher-DOI
Text Version
Author
Rights
© Springer-Verlag Berlin Heidelberg 2017
Citation
This is a post-peer-review, pre-copyedit version of an article published in [ Kawashima, F., Saito, K., Kurata, H. et al. Histochem Cell Biol (2017) 147: 721. https://doi.org/10.1007/s00418-016-1536-2 ]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00418-016-1536-2
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English