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Title Transcription
ケイトウガイ ジキ シゲキホウ ニ ヨル シンケイ シッカン ノ ウンドウヤ コウフンセイ キコウ イジョウ ノ ケンシュツ
Title Alternative
Changes in the motor cortical excitability in neurological disorders
Authors
Hanashima, Ritsuko Department of Neurology, Division of Neurology, Department of Brain and Neurosciensces, Faculty of Medicine, Tottori University Researchers DB KAKEN
Keywords
Motor cortex
Cerebellum
Basal ganglia
Transcranial magnetic stimulation
Involuntary movements
Abstract
Several condition-test paradigms using transcranial magnetic stimulation (TMS) have been recently developed to study motor cortical (M1) excitability changes in human. The short interval intra-cortical inhibition (SICI),interheispheric inhibition (IHI) and cerebellar inhibition (CBI) are widely used methods to evaluate M1 modulation through intrinsic GABAergic neurons, callosal fibers, and cerebellum-thalamus-M1 pathways, respectively. We studied these modulations in several neurological disorders. The SICI was abnormally reduced in cortical myoclonus, focal dystonia or Parkinson’s disease. In contrast, it was normal in chorea or essential tremor. The GABAergic dysfunction may be produced by GABA reduction within M1 or abnormal M1 regulation from the basal ganglia. The IHI was reduced in mild cognitive imparment patients and cortical myoclonus. This may be due to GABAergic dysfunction within the cortex. The CBI was decreased in patients with many kinds of cerebellar ataxia, progressive nuclear palsy (PSP),and essential tremor (ET).Because it tests the function of cerebello-cerebellar connection, we first showed cerebellar dysfunction in PSP and ET who have no clinical cerebellar symptoms. TMS has enable us to study the human central nervous system function physiologically.
Publisher
米子医学会
Content Type
Departmental Bulletin Paper
Link
ISSN
00440558
NCID
AN00247383
Journal Title
米子医学雑誌
Current Journal Title
The Journal of the Yonago Medical Association
Volume
69
Issue
6
Start Page
61
End Page
65
Published Date
2018-11-30
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
花島律子. 経頭蓋磁気刺激法による神経疾患の運動野興奮性機構異常の検出. 米子医学雑誌. 2018, 69(6), 61-65.
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
Japanese