ID 8409
フルテキストファイル
著者
小山 哲史 Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧
藤原 和典 Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧 KAKEN
野坂 加苗 Division of Organ Pathology, Department of Microbiology and Pathology, Tottori University Faculty of Medicine 研究者総覧
福原 隆宏 Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Morisaki, Tsuyoshi Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine
三宅 成智 Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Kitano, Hiroya Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine / Center for Head and Neck Surgery, Kusatsu General Hospital
竹内 裕美 Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
Autopsy
Paired box 8
PAX8
Squamous cell carcinoma
Thyroid
抄録
Primary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported in < 1% of all thyroid cancer cases. Primary SCC in the thyroid was thought to be a transitional form derived from adenocarcinomas; therefore, the majority of reported cases have focused on the conjunction with other histological adenocarcinomas. A 73-year-old male presented to our hospital with bilateral vocal fold palsy and an anterior neck mass. Ultrasound sonography revealed a bulky tumor in the thyroid and bilateral cervical lymphadenopathy. We performed fine-needle aspiration cytology from the thyroid tumor, which revealed SCC. Positron emission tomography/computed tomography showed distant metastases in the lungs, mediastinal lymph nodes, and vertebra. We diagnosed the patient as having stage IVC SCC in the thyroid and administered weekly paclitaxel. Four and a half months after treatment initiation, the tumor progression resulted in aspiration pneumonia, which proved fatal. We performed an autopsy in accordance with the patient’s wishes. Pathological findings revealed that all carcinomas in the thyroid, cervical lymph nodes, and lungs were pure SCCs. Immunohistochemical examinations for PAX8, thyroglobulin, and TTF-1 were all negative. Differentiated thyroid carcinomas have 3 major positive markers – PAX8, thyroglobulin, and TTF-1 –, and PAX8 is also sometimes positive for SCC in the thyroid. PAX8 positivity of SCC in the thyroid might, however, be associated with conjunction with other histological adenocarcinomas such as papillary or follicular thyroid carcinoma; therefore, pure SCC in the thyroid might be negative for PAX8.
出版者
S. Karger AG
資料タイプ
学術雑誌論文
外部リンク
ISSN
16626575
掲載誌名
CASE REPORTS IN ONCOLOGY
最新掲載誌名
CASE REPORTS IN ONCOLOGY
11
2
開始ページ
418
終了ページ
424
発行日
2018
出版者DOI
著者版フラグ
出版社版
著作権表記
© 2018 The Author(s) Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
掲載情報
Koyama Satoshi, Fujiwara Kazunori, Nosaka Kanae, et al. Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case. CASE REPORTS IN ONCOLOGY. 2018. 11(2). 418-424. doi:10.1159/000490410
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000455063400027