ID 9080
フルテキストファイル
著者
Murata, Akihiko Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Hikosaka, Mari Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine
Yoshino, Miya Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University 研究者総覧
Zhou, Lan Department of Pathology, Case Western Reserve University
Hayashi, Shin-ichi Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
Delta-like
Jagged
抄録
Kit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by Notch family members. On stromal cells transduced with each Notch ligand gene, Kit and its signaling become dispensable for the entire adhesion process of MCs from tethering to spreading. The Notch-mediated spreading of adherent MCs involves the activation of signaling via phosphatidylinositol 3-kinases and mitogen-activated protein kinases, similar to Kit-mediated spreading. Despite the activation of the same signaling pathways, while Kit supports the adhesion and survival of MCs, Notch only supports adhesion. Thus, Notch family members are specialized adhesion molecules for MCs that effectively replace the adhesion function of Kit in order to support the interaction of MCs with the surrounding cellular microenvironments.
出版者
Oxford University Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
09538178
EISSN
14602377
掲載誌名
INTERNATIONAL IMMUNOLOGY
最新掲載誌名
INTERNATIONAL IMMUNOLOGY
31
2
開始ページ
69
終了ページ
79
発行日
2019-02
出版者DOI
著者版フラグ
著者版
著作権表記
This is a pre-copyedited, author-produced version of an article accepted for publication in INTERNATIONAL IMMUNOLOGY following peer review. The version of record Akihiko Murata, Mari Hikosaka, Miya Yoshino, Lan Zhou, Shin-Ichi Hayashi, Kit-independent mast cell adhesion mediated by Notch, International Immunology, Volume 31, Issue 2, February 2019, Pages 69–79, https://doi.org/10.1093/intimm/dxy067 is available online at: https://doi.org/10.1093/intimm/dxy067
掲載情報
Murata Akihiko, Hikosaka Mari, Yoshino Miya, et al. Kit-independent mast cell adhesion mediated by Notch. INTERNATIONAL IMMUNOLOGY. 2019. 31(2). 69-79. doi:10.1093/intimm/dxy067
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000461515600002