フルテキストファイル
著者
Ikeda, Ryoukichi Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
Ohta, Nobuo Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
Fukaya, Sachiko Division of Pathology, Tohoku Medical and Pharmaceutical University
Shoji, Fumi Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
Suzuki, Takahiro Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
Noguchi, Naoya Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
Kakuta, Risako Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
Hayashi, Kazuhiko Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Kida, Takayoshi Laboratory of Gastrointestinal Regenerative Medicine, Okayama University of Science
Murakami, Kazuhiro Division of Pathology, Tohoku Medical and Pharmaceutical University
Nakamura, Yasuhiro Division of Pathology, Tohoku Medical and Pharmaceutical University
キーワード
head and neck
lymph node
Merkel cell carcinoma
neck lymph node dissection
neuroendocrin
抄録
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. To diagnose nodal MCC with an unknown primary disease is challenging, and it has to be separated from other nodal metastatic neoplasms. We report a unique case of nodal MCC in head and neck lesions with an unknown primary. A 70-year-old woman was admitted to our department with a right submandibular mass. Fine needle aspiration biopsy was performed and indicated malignancy. F-18-fluorodeoxyglucose positron emission tomography (PET) demonstrated abnormal accumulation in the right submandibular lymph node, right palatine tonsil, and right thyroid gland. For diagnostics and treatment, bilateral selective neck lymph node dissection, right tonsillectomy, and right thyroidectomy were performed. Histopathological examination revealed that most parts of the submandibular lymph node were occupied by diffuse sheets of tumor cells. Contrary to our expectation, malignant cells were not detected in the right palatine tonsil and right thyroid. Immunohistochemistry demonstrated a marked positive reaction for AE1/AE3, chromogranin A, synaptophysin, cytokeratin 20 (CK20) and CD56 and a negative reaction for vimentin, leucocyte common antigen (LCA), thyroid transcription factor-1 (TTF1) and cytokeratin 7 (CK7) in the tumor cells. Immunostaining of Merkel cell polyomavirus-large T antigen (MCPyV-LT) showed a positive reaction and MCPyV-positive MCCs were assessed by PCR analysis, demonstrating that viral copy number was 12.8 copies per cell. These histological findings confirmed the diagnosis of Merkel cell carcinoma of the lymph node. In cases of tumors in the lymph node with a neuroendocrine appearance in head and neck lesions, it is necessary to eliminate the possibility of metastasis from MCC.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
05135710
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
62
3
開始ページ
258
終了ページ
262
Patient Report
発行日
2019-09-13
出版者DOI
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
掲載情報
Ikeda R, Ohta N, Fukaya S, Shoji F, Suzuki T, Noguchi N, et al. Nodal Merkel Cell Carcinoma in Head and Neck Lesions with an Unknown Primary: A Case Report in Light of the Literature. Yonago Acta Medica. 2019;62:258-262.
部局名
医学部・医学系研究科・医学部附属病院
言語
英語