フルテキストファイル
著者
Fukumoto Yoji Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Yamada Yoshinori Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Fukuda Kenji Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Saito Hiroaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Tatebe Shigeru Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tsujitani Shunichi Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Ikeguchi Masahide Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN
キーワード
fibroblast activation protein
gastric cancer
immunohistochemistry
prognosis
抄録
Human fibroblast activation protein (FAP) is a 97-kDa surface glycoprotein expressed in tumor-associated fibroblasts. In this study, we immunohistochemically examined FAP levels in surgically resected gastric carcinomas and explored their association with clini-copathological findings and prognosis. Sections of paraffin-embedded specimens were obtained from 100 patients with advanced gastric cancer between 1989 and 2001 at our institution, and they were stained with an anti-FAP antibody. Expression of FAP was detected in 64 patients (64%). Lymphatic vessel invasion was observed in 90% of FAP-positive patients (P = 0.015). Blood vessel invasion was observed in 98% of FAP-positive patients (P < 0.001). The disease-specific 5-year survival rate of in the 64 patients with FAP-positive tumors (22%) was significantly lower than in the 36 patients with FAP-negative tumors (34%, P = 0.036). This indicates that vessel invasion is connected with the expression of FAP and that a positive finding of FAP confer a worse prognosis in the patients with gastric cancer.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
52
1
開始ページ
21
終了ページ
25
発行日
2009-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2009, 52(1), 21-25
部局名
医学部・医学系研究科・医学部附属病院
言語
英語