フルテキストファイル
著者
Isoyama Tadahiro Department of Urology, Faculty of Medicine, Tottori University
Sofikitis Nikolaos Department of Urology, Faculty of Medicine, Tottori University
キーワード
growth factors
testis
spermatozoa
varicocele
抄録
We evaluated whether alterations in testicular vascularization and fluid dynamics have a role in the development of testicular damage in varicocelized animals. Left varicocele was induced in 6 groups of rats (A, B, C, D, E and F; 7 rats in each group). Four times a week, rats of group A, B, C, D, E and F underwent intrascrotal injections of saline, insulin-like growth factor-I, fibroblast growth factor, tumor necrosis factor-α, vascular endothelial growth factor or all the previous factors together, respectively. Additionally 7 rats were sham-operated (group G). At 8 weeks post-operation, groups E, F and G showed significantly higher left epididymal sperm content and motility, testosterone responses to human chorionic gonadotropin stimulation and intraabdominal versus intratesticular temperature differences than group A. Histological sections showed that the number of vessels per seminiferous tubule was significantly larger in groups E and F than in group A. Factors inducing vascularization have a beneficial effect on the function of the varicocelized testis attributable to improvement of testicular tissue nutrition or to amelioration of the functionality of the countercurrent heat exchange system.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
42
1
開始ページ
41
終了ページ
49
発行日
1999-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1999, 42(1), 41-49
部局名
医学部・医学系研究科・医学部附属病院
言語
英語