フルテキストファイル
著者
Kaetsu Akihiko Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine KAKEN
Kishimoto Takuji Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine KAKEN
Osaki Yoneatsu Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Okamoto Mikizoh Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine KAKEN
Kurozawa Yoichi Division of Health Administration and Promotion, Department of Social Medicine, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
angiotensinogen
polymorphism (genetics)
cholesterol
cross-sectional study
Japanese workers
抄録
Angiotensinogen (AGT) is a component of the renin-angiotensin system, which plays a central role in blood pressure regulation. Although it is controversial, the association between AGT gene polymorphisms and hypertension, and coronary heart disease is suspected. In a case-control study on the metabolic syndrome, an association between AGT M235T polymorphism and serum total cholesterol (TC) level was demonstrated by Thomas et al. (2001). To reconfirm this relationship, a cross-sectional study among Japanese workers with 876 dyslipidemia and 1,158 non-dyslipidemia subjects was carried out. To evaluate the AGT M235T polymorphism, a PCR-mutant allele specific amplification (MASA) method was employed. No significant difference in the distribution of genetic variance was observed between the two groups. Although it was not significant, the T allele correlating to the lower TC of the present study occurred in a reversed manner to the previous report. In our results, no significant association between AGT M235T and TC was observed.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
49
1
開始ページ
49
終了ページ
58
発行日
2006-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2006, 49(1), 49-58
部局名
医学部・医学系研究科・医学部附属病院
言語
英語