フルテキストファイル
著者
Maeta Michio Department of Fundamental Nursing, Tottori University Faculty of Medicine KAKEN
Oka Shinichi First Department of Surgery, Tottori University Faculty of Medicine
Saito Hiroaki First Department of Surgery, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Ikeguchi Masahide First Department of Surgery, Tottori University Faculty of Medicine KAKEN
Tsujitani Shunichi First Department of Surgery, Tottori University Faculty of Medicine
Kaibara Nobuaki First Department of Surgery, Tottori University Faculty of Medicine KAKEN
キーワード
gastric cancer
nutritional marker
plasma leptin level
抄録
Leptin, a product of the obese gene, is synthesized and released into the circulation in response to increased energy storage in adipose tissue. Leptin plays an important role in the regulation of body weight and energy balance. However, leptin levels in patients with malignant tumor have not been fully examined. The purpose of the present study is to clarify the clinical implications of leptin levels in the circulation in patients with gastric cancer. The subjects were 103 patients with gastric cancer at various stages. Levels of leptin in the plasma were determined with a commercially available human leptin-selective quantitative enzyme immunoassay kit. There were clear decreasing trends in leptin levels along with tumor progression in both males and females, and statistically significant differences were observed in males between stages II and IV, and in females between stages I and IV. Plasma leptin levels of females were consistently higher than those of males when we compared them with patients in the same stages. Moreover, statistically significant decreases in leptin levels were observed postoperatively. However, there were no statistically significant relationships between leptin levels and clinicopathological findings. There was a positive correlation between levels of plasma leptin and values of the body mass index. These findings may indicate that plasma leptin levels do not involve factors relevant to specific tumor growth but involve some tumor-related nutritional status due to tumor progression. We conclude that leptin levels are reflected during tumor-bearing status, and these are also useful markers for both indicating tumor progression and discovering the nutritional status of patients with gastric cancer.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
44
3
開始ページ
143
終了ページ
149
発行日
2001-11
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2001, 44(3), 143-149
部局名
医学部・医学系研究科・医学部附属病院
言語
英語