フルテキストファイル
著者
Maeta Michio First Department of Surgery, Faculty of Medicine, Tottori University KAKEN
Cai Jianhui First Department of Surgery, Faculty of Medicine, Tottori University
Oka Shinichi First Department of Surgery, Faculty of Medicine, Tottori University
Saito Hiroaki First Department of Surgery, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Kondo Akira First Department of Surgery, Faculty of Medicine, Tottori University KAKEN
Tsujitani Shunichi First Department of Surgery, Faculty of Medicine, Tottori University
Ikeguchi Masahide First Department of Surgery, Faculty of Medicine, Tottori University KAKEN
Kaibara Nobuaki First Department of Surgery, Faculty of Medicine, Tottori University KAKEN
キーワード
cytokeratin
gastric cancer
lymph nodes
micrometastases
prognosis
抄録
Detection of occult metastases in lymph nodes by immunostaining is becoming of increasing interest as a way to improve the accuracy of predicting the prognosis for patients with gastric cancer. Immunohistochemical detection of cytokeratin (CK) is recognized as the most sensitive method for identification of cancerous epithelial cells. In this study, lymph nodes were stained for CK in an effort to detect micrometastases and the clinical implications of the results were examined. We immunostained sections from a total of 1,198 lymph nodes from 25 totally gastrectomized patients with T3 or T4 gastric cancer who had been diagnosed as having no nodal involvement by conventional hematoxylin-eosin (HE) staining. Eighty (6.7%) of 1,198 lymph nodes from 15 (60%) of the 25 patients were immunostained with a CK-specific monoclonal antibody. CK-positive cells were more frequent in patients with macroscopic types of 3,4 and 5 gastric cancer. Patients with nodes that were both HE-negative and CK-negative had the best postoperative survival, followed by patients with HE-negative and CK-positive nodes and, finally, by patiof micrometastases in lymph nodes is a reliable indicator of the prognosis of patients with advanced gastric cancer.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
41
3
開始ページ
105
終了ページ
112
発行日
1998-11
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1998, 41(3), 105-112
部局名
医学部・医学系研究科・医学部附属病院
言語
英語