フルテキストファイル
著者
Kishimoto Takuji Department of Hygiene, Tottori University Faculty of Medicine KAKEN
Suyama Akihiko Department of Hygiene, Tottori University Faculty of Medicine KAKEN
Osaki Yoneatsu Department of Hygiene, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Miyamoto Tetsuya Department of Hygiene, Tottori University Faculty of Medicine
Igarashi Atsusi Department of Hygiene, Tottori University Faculty of Medicine
Okamoto Mikizoh Department of Hygiene, Tottori University Faculty of Medicine KAKEN
Kurosawa Yoichi Department of Public Health, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Fukumoto Soji Department of Parasitology, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
angiotensinogen
case-control study
genotype
hypertension
polymorphism
抄録
In order to examine the distribution of M235T (the substitution of threonine for 0methionine at position 235 codon) polymorphism genotypes of the angiotensinogen (AGT) gene and the relationship between M235T polymorphism of the AGT gene and hypertension, a descriptive study and a case-control study were performed among Japanese workers. The subjects were 2042 workers at an occupational site in Shimane Prefecture in Japan. The database was set up for the workers' regular health examination in 1998. The M235T polymorphism of the AGT gene for each worker was defined by the mutant allele specific amplification (MASA) method. The rates of M235M (MM), M235T (MT) and T235T (TT) genotypes were 3.9%, 30.7% and 65.5%, respectively. The odds ratios of MT and TT against MM for hypertension by univariate analysis were 0.77 [95% confidence interval (CI) 0.27-2.18] and 0.77 (95% CI 0.28-2.14), respectively. The odds ratios of MT and TT against MM for hypertension, adjusted for body mass index, fasting blood sugar, drinking habits, cigarette smoking and exercise in a logistic regression model, were 0.90 (95% CI 0.29-2.74) and 0.87 (95% CI 0.30-2.58), respectively. The data from this study suggests that there may be no relationship between the M235T polymorphism of the AGT gene and hypertension. Further prospective studies are needed to resolve this issue.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
44
1
開始ページ
79
終了ページ
83
発行日
2001-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2001, 44(1), 79-83
部局名
医学部・医学系研究科・医学部附属病院
言語
英語