フルテキストファイル
著者
Okada Hirofumi Second Department of Internal Medicine, Tottori University
Suyama Akihiko Department of Hygiene, Faculty of Medicine, Tottori University KAKEN
Osaki Yoneatsu Department of Hygiene, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Okamoto Mikizo Department of Hygiene, Faculty of Medicine, Tottori University KAKEN
Yamamoto Toshiyuki Gene Research Center, Tottori University
Nanba Eiji Gene Research Center, Tottori University 研究者総覧 KAKEN
Kishimoto Takuji Department of Hygiene, Faculty of Medicine, Tottori University KAKEN
キーワード
β3-Adrenergic receptor
impaired glucose tolerance
multiple risk factors
non-insulin-dependent diabetes mellitus
Trp64Arg polymorphism
抄録
In order to investigate whether the Trp64Arg (a missense mutation of tryptophan for arginine at position 64 codon) polymorphism of the β3-adrenergic receptor (β3-AR) gene is related to the incidence of non-insulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT), a retrospective cohort study among Japanese workers was conducted. The subjects were Japanese workers at an occupational site in Shimane Prefecture. Informed consent was obtained from 492 workers. The baseline data were obtained at the regular health examination in 1992 and a retrospective cohort study was performed for analyzing the incidence of NIDDM and IGT in 1998. The Trp64Arg polymorphism β3-AR gene for each worker was detected by the single strand conformation polymerase analysis. Relative risks were calculated by the logistic regression analysis. The rates of Trp64Trp (TT), Trp64Arg (TA) and Arg64Arg (AA) genotypes were 66.3%, 31.1% and 2.6%, respectively. The relative risk of (TA + AA) against TT for the incidence of NIDDM and IGT by univariate analysis was 1.37 (95% incidence of NIDDM and IGT adjusted for confounders in a multiple logistic regression model including age, gender, family history, body mass index, alcohol consumption, eating habits and exercise was 1.31 (95% confidence interval, 0.65-2.67). The present findings suggested that a weak association between Trp64Arg polymorphism of the β3-AR gene and the incidence of NIDDM and IGT.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
44
1
開始ページ
55
終了ページ
59
発行日
2001-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2001, 44(1), 55-59
部局名
医学部・医学系研究科・医学部附属病院
言語
英語