yam60(3)_145.pdf 3.33 MB
Matsushita Michiko Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Iwasaki Takeshi Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
Nonaka Daisuke Department of Histopathology, The Christie NHS Foundation Trust
Kuwamoto Satoshi Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Nagata Keiko Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Kato Masako Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Kitamura Yukisato Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine 研究者総覧 KAKEN
activation-induced cytidine deaminase
Merkel cell carcinoma
Merkel cell polyomavirus
[Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV).
[Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs.
[Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients.
[Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones.
Tottori University Faculty of Medicine
Yonago Acta Medica
Yonago Acta Medica
Yonago Acta Medica. 2017, 60(3), 145-153