フルテキストファイル
著者
Iida, Yuki Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University
Komatsu, Hiroaki Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University
Okawa, Masayo Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University
Osaku, Daiken Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University
野坂 加苗 Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧
佐藤 慎也 Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
大石 徹郎 Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
谷口 文紀 Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
原田 省 Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
endometrial cancer
lymphovascular space invasion
prognosis
recurrent risk
抄録
Background: We investigated whether there was a difference in prognosis between patients with stage IA endometrial cancer with and without lymphovascular space invasion. Methods: We enrolled patients with stage IA (pT1aN0M0) endometrial cancer admitted to our hospital from 2009 to 2018. All patients underwent hysterectomy, bilateral salpingo-oophorectomy, and systematic pelvic lymphadenectomy. We immunopathologically evaluated the presence or absence of lymphovascular space invasion in the tumor tissue using hematoxylin and eosin, Elastica-van Gieson, and podoplanin staining. We analyzed disease-free and overall survival and calculated patients’ survival distribution using the Kaplan–Meier method and log-rank test. The multivariate analysis was performed to determine the prognostic factors. Results: A total of 116 patients were included. The median age of the patients was 57 (range, 30–78) years, and the histological subtype revealed 98 and 18 cases of types 1 and 2, respectively. The median follow-up period was 71.9 (range, 10.8–149) months, and the 3-year disease-free and 3-year overall survival rates were 94% and 99%, respectively. The disease-free and overall survival rates were significantly shorter in type 2 patients than in type 1 patients (type 2 vs. type 1; 77% vs. 97%, P < 0.01, 94% vs. 100%, P = 0.014, respectively). The univariate and multivariate analyses showed that there were no significant differences in disease-free survival between the lymphovascular space invasion-positive and -negative groups among type 1 cases. Conclusion: There was no difference in prognosis between patients with stage IA and type 1 endometrial cancer with and without lymphovascular space invasion.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
05135710
EISSN
13468049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
65
1
開始ページ
82
終了ページ
87
発行日
2022-02-22
出版者DOI
著者版フラグ
出版社版
著作権表記
(C) 2022 Tottori University Medical Press.
掲載情報
Yonago Acta Medica. 2022, 65(1), 82-87. doi10.33160/yam.2022.02.014
部局名
医学部・医学系研究科・医学部附属病院
言語
英語