フルテキストファイル | |
著者 |
Kaetsu Akihiko
Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine
KAKEN
Kishimoto Takuji
Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine
KAKEN
Osaki Yoneatsu
Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine
研究者総覧
KAKEN
Okamoto Mikizoh
Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine
KAKEN
Kurozawa Yoichi
Division of Health Administration and Promotion, Department of Social Medicine, School of Medicine, Tottori University Faculty of Medicine
研究者総覧
KAKEN
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キーワード | angiotensinogen
polymorphism (genetics)
cholesterol
cross-sectional study
Japanese workers
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抄録 | Angiotensinogen (AGT) is a component of the renin-angiotensin system, which plays a central role in blood pressure regulation. Although it is controversial, the association between AGT gene polymorphisms and hypertension, and coronary heart disease is suspected. In a case-control study on the metabolic syndrome, an association between AGT M235T polymorphism and serum total cholesterol (TC) level was demonstrated by Thomas et al. (2001). To reconfirm this relationship, a cross-sectional study among Japanese workers with 876 dyslipidemia and 1,158 non-dyslipidemia subjects was carried out. To evaluate the AGT M235T polymorphism, a PCR-mutant allele specific amplification (MASA) method was employed. No significant difference in the distribution of genetic variance was observed between the two groups. Although it was not significant, the T allele correlating to the lower TC of the present study occurred in a reversed manner to the previous report. In our results, no significant association between AGT M235T and TC was observed.
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出版者 | Tottori University Faculty of Medicine
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資料タイプ |
学術雑誌論文
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ISSN | 1346-8049
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書誌ID | AA00892882
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掲載誌名 | Yonago Acta medica
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最新掲載誌名 |
Yonago Acta medica
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巻 | 49
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号 | 1
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開始ページ | 49
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終了ページ | 58
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発行日 | 2006-03
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著者版フラグ |
出版社版
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著作権表記 | Yonago Acta medica 編集委員会
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掲載情報 | Yonago Acta medica. 2006, 49(1), 49-58
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部局名 |
医学部・医学系研究科・医学部附属病院
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言語 |
英語
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