フルテキストファイル
著者
高野 周一 Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧
Hasegawa, Toshimichi Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University
Masuda, Kohga Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University
花木 武彦 Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧
徳安 成郎 Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧
坂本 照尚 Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧
野坂 加苗 Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧
藤原 義之 Department of Gastrointestinal and Pediatric Surgery, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
biliary tract cancer
congenital biliary dilatation
pancreaticobiliary maljunction
precancerous lesion
pyloric gland metaplasia
抄録
Pyloric gland metaplasia in the biliary epithelium is a precancerous lesion and has been confirmed in patients with congenital biliary dilatation presenting with overt biliary tract cancer. A patient was found to have an intra-abdominal cyst on fetal ultrasonography and was born at 37 weeks of gestation with a body weight of 2,636 g. Abdominal distension and repeated vomiting appeared 2 days after birth. Congenital biliary dilatation was diagnosed by imaging, wherein the common bile duct was enlarged to 9–10 cm in size, and the surrounding organs were extensively compressed; however, there was no sign of pancreatitis or cholangitis. Biliary drainage was performed through the gallbladder at 6 days of age, but it was insufficient because of the narrow and twisted cystic duct and changed to common bile duct at 18 days to relieve the compression. Because the body weight gain was poor due to loss of large amount of bile, the dilated bile duct and gallbladder were resected and hepatic duct Roux-Y jejunostomy was performed at 115 days of age with 4,500 g of body weight. Intraoperative imaging showed a pancreaticobiliary maljunction, and the pancreatic enzyme activities of the bile in the biliary system were remarkably elevated. Histopathological examination revealed pyloric gland metaplasia in the gallbladder epithelium and cystic duct. The patient is now over 2 years old and has been doing well without any complications. Based on our experience, precancerous pyloric gland metaplasia of the biliary epithelium may already occur even in a 3-month-old infant presenting with congenital biliary dilatation.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
05135710
EISSN
13468049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
65
1
開始ページ
96
終了ページ
100
発行日
2022-02-22
出版者DOI
著者版フラグ
出版社版
著作権表記
(C) 2022 Tottori University Medical Press.
掲載情報
Yonago Acta Medica. 2022, 65(1), 96-100. doi10.33160/yam.2022.02.007
部局名
医学部・医学系研究科・医学部附属病院
言語
英語