フルテキストファイル
著者
Wei Zheng Qiang Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Maeta Michio Department of Fundamental Nursing, School of Health Sciences, Tottori University Faculty of Medicine KAKEN
Yoshida Haruhiko Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine KAKEN
Ikeguchi Masahide Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN
Tsujitani Shunichi Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Kaibara Nobuaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN
キーワード
cytokeratin
gastric cancer with subserosal invasion
hematoxylin-eosin staining
immunohistochemical staining
serosal microinvasion
抄録
In gastric cancer, the presence or absence of serosal invasion by cancer in the primary lesion is an important prognostic factor. Pathological findings are routinely determined by hematoxylin-eosin (H&E) staining, but it is well known that micrometastasis or microinvasion are easily overlooked by H&E staining. Cytokeratin (CK) proteins serve as reliable markers for cells from epithelial origins. The purpose of this study was to clarify the usefulness of CK immunohistochemical staining in the detection of serosal microinvasion in gastric cancer with subserosal invasion. We examined 50 primary lesions from 50 gastric cancer patients with subserosal invasion. Two consecutive sections were prepared for simultaneous staining with ordinary H&E and CK immunostaining with anticytokeratin antibody (CAM 5.2), respectively. Although there were no differences in the postoperative survival rates between patients with or without microinvasion, serosal microinvasion was 0detected in 8 (16%) of 50 patients by CK staining, including 1 patient whose invasion was detected by both H&E and CK stainings. CK immunostaining enabled us to make an accurate and detailed diagnosis which we believe to be useful for detecting serosal microinvasion in the primary lesion in gastric cancer with subserosal invasion.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
46
4
開始ページ
125
終了ページ
131
発行日
2003-12
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2003, 46(4), 125-131
部局名
医学部・医学系研究科・医学部附属病院
言語
英語