フルテキストファイル
著者
Ehara, Yuko Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine,Tottori University
Yamamoto, Osamu Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Kosaki, Kenjiro Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University
Yoshida, Yuichi Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
cutaneous neurofibroma
distribution
neurofibromatosis 1
NF1
predilection body site
抄録
Neurofibromatosis 1 (NF1) is characterized by cutaneous, neurological and osseous manifestations. Most NF1 patients develop cutaneous neurofibromas. However, time‐dependent change with aging and the predilection site of cutaneous neurofibromas remain unclear. To clarify the natural course and characteristics of cutaneous neurofibromas, a retrospective study was conducted for 57 NF1 patients who were treated at the Department of Dermatology of Tottori University Hospital between January 2007 and April 2016. For each patient, we investigated the time‐dependent changes and the numbers of cutaneous neurofibromas in four body surface regions. There was a positive correlation between age and number of cutaneous neurofibromas (r = 0.75, P < 0.001). Cutaneous neurofibromas were located on the trunk (60.2%), lower limbs (16.1%), upper limbs (14.4%), and head and neck (9.2%). There was no significant relationship between each body type (e.g. obese or thin) and cutaneous neurofibromas. With respect to the year‐to‐year percentage change in cutaneous neurofibromas, the average annual rate of increase was 0.21 (range, −0.71 to 1.2). The number of cutaneous neurofibromas had increased in approximately 61% of the patients 1 year later. Our data will enable physicians to estimate the overall state of cutaneous neurofibromas in NF1 and will be useful for handling cutaneous manifestations before they become a serious condition.
出版者
WILEY
資料タイプ
学術雑誌論文
外部リンク
ISSN
03852407
EISSN
13468138
書誌ID
AA00696658
掲載誌名
JOURNAL OF DERMATOLOGY
最新掲載誌名
JOURNAL OF DERMATOLOGY
45
1
開始ページ
53
終了ページ
57
発行日
2018
出版者DOI
著者版フラグ
著者版
著作権表記
(C) 2017 Japanese Dermatological Association
掲載情報
Ehara Yuko, Yamamoto Osamu, Kosaki Kenjiro, et al. Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. JOURNAL OF DERMATOLOGY. 2018. 45(1). 53-57. doi:10.1111/1346-8138.14025
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000419601100020