フルテキストファイル
著者
Yoshida, Yuichi Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Ehara, Yuko Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Koga, Monji Department of Dermatology, Fukuoka University School of Medicine
Imafuku, Shinichi Department of Dermatology, Fukuoka University School of Medicine
Yamamoto, Osamu Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
neurofibromatosis 1
epidemiology
treatment
survey
抄録
Neurofibromatosis 1 has various complications. To elucidate the frequency of neurofibromatosis 1-related major complications requiring medical intervention, a nationwide retrospective study was conducted of 3,530 patients with neurofibromatosis 1 registered from 2001 to 2014 in Japan. The ratio of certified patients requiring medical intervention (>stage 3) was 82%. Patients classified in the most severe grade experienced dermatological complications (71.8% of patients), neurological complications (38.1%) and bone complications (33.3%). In patients with dermatological manifestations, medical treatment was needed for cutaneous neurofibromas (58%), diffuse plexiform neurofibromas (31%) and malignant peripheral nerve sheath tumours (10%). Patients with neurological manifestations needed medical treatment mainly for brain tumours (53%) and intellectual disability (26%). Patients with bone manifestations needed medical treatment for pseudoarthrosis (9%), scoliosis (55%) and bone defects (16%). It is necessary for physicians to be aware of neurofibromatosis 1-related complications requiring medical intervention in order to provide appropriate care for patients with neurofibromatosis 1.
出版者
ACTA DERMATO-VENEREOLOGICA
資料タイプ
学術雑誌論文
外部リンク
ISSN
00015555
EISSN
16512057
書誌ID
AA00507245
掲載誌名
ACTA DERMATO-VENEREOLOGICA
最新掲載誌名
ACTA DERMATO-VENEREOLOGICA
98
8
開始ページ
753
終了ページ
756
発行日
2018-09-15
出版者DOI
著者版フラグ
出版社版
著作権表記
This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta Journal Compilation (C) 2018 Acta Dermato-Venereologica.
掲載情報
Yoshida Yuichi, Ehara Yuko, Koga Monji, et al. Epidemiological Analysis of Major Complications Requiring Medical Intervention in Patients with Neurofibromatosis 1. ACTA DERMATO-VENEREOLOGICA. 2018. 98(8). 753-756. doi:10.2340/00015555-2975
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000442511400006