フルテキストファイル
著者
Ehara, Yuko Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Koga, Monji Department of Dermatology, Fukuoka University School of Medicine,
Imafuku, Shinichi Department of Dermatology, Fukuoka University School of Medicine,
Yamamoto, Osamu Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Yoshida, Yuichi Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
distribution
neurofibromatosis 1
plexiform neurofibroma
predilection body site
selumetinib
抄録
Neurofibromatosis 1 (NF1) is a genetic disease characterized by cutaneous, neurological and osseous abnormalities. Approximately 20% of patients develop plexiform neurofibroma (PN), resulting in impaired quality of life. To evaluate distribution of diffuse PN on the body surface, a retrospective study was conducted for 354 patients with NF1 from 2007 to 2018 in Japan. We investigated a total of 40 patients with clinically apparent superficial diffuse PN. In the cases evaluated, 57.4% of the diffuse PN were located on the trunk, 19.2% the head and neck, 12.8% the lower limbs and 10.6% the upper limbs. Remarkably, 75.0% of the diffuse PN were located on the dorsal side. The frequency was significantly higher on the trunk than on the head and neck (P = 0.026). Our findings provide useful information for giving attention to the high possibility of diffuse PN on the dorsal side before progression in childhood and for future treatment in NF1.
出版者
WILEY
資料タイプ
学術雑誌論文
外部リンク
ISSN
03852407
EISSN
13468138
書誌ID
AA00696658
掲載誌名
JOURNAL OF DERMATOLOGY
最新掲載誌名
JOURNAL OF DERMATOLOGY
47
2
開始ページ
190
終了ページ
192
発行日
2020-02
出版者DOI
著者版フラグ
著者版
著作権表記
(C) 2019 Japanese Dermatological Association
掲載情報
Ehara Yuko, Koga Monji, Imafuku Shinichi, et al. Distribution of diffuse plexiform neurofibroma on the body surface in patients with neurofibromatosis 1. JOURNAL OF DERMATOLOGY. 2020. 47(2). 190-192. doi:10.1111/1346-8138.15194
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000502963700001