Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

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著者	Koizumi, Ryo Graduate School of Engineering, Tottori University Azuma, Kazuo Department of Veterinary Clinical Medicine, Tottori University 研究者総覧 KAKEN Izawa, Hironori Graduate School of Engineering, Tottori University 研究者総覧 KAKEN Morimoto, Minoru Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University 研究者総覧 KAKEN Ochi, Kosuke Department of Veterinary Clinical Medicine, Tottori University Tsuka, Takeshi Department of Veterinary Clinical Medicine, Tottori University 研究者総覧 KAKEN Imagawa, Tomohiro Department of Veterinary Clinical Medicine, Tottori University 研究者総覧 KAKEN Osaki, Tomohiro Department of Veterinary Clinical Medicine, Tottori University 研究者総覧 KAKEN Ito, Norihiko Department of Veterinary Clinical Medicine, Tottori University 研究者総覧 KAKEN Okamoto, Yoshiharu Department of Veterinary Clinical Medicine, Tottori University 研究者総覧 KAKEN Saimoto, Hiroyuki Graduate School of Engineering, Tottori University 研究者総覧 KAKEN Ifuku, Shinsuke Graduate School of Engineering, Tottori University 研究者総覧 KAKEN
キーワード	surface deacetylated chitin nanofiber chitosan mucositis 5-fluorouracil apoptosis
抄録	This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
出版者	MDPI
資料タイプ	学術雑誌論文
外部リンク	https://www.mdpi.com/1422-0067/18/2/279
ISSN	14220067
書誌ID	AA12038549
掲載誌名	International Journal of Molecular Sciences
巻	18
号	2
開始ページ	279
発行日	2017-01-27
出版者DOI	10.3390/ijms18020279
著者版フラグ	出版社版
著作権表記	© 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
掲載情報	KOIZUMI, Ryo, et al. Oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fluorouracil-induced intestinal mucositis in mice. International journal of molecular sciences, 2017, 18.2: 279. https://doi.org/10.3390/ijms18020279
部局名	工学部・工学研究科
言語	英語