フルテキストファイル
著者
Matsunaga, Tomoyuki Department of Digestive Surgery, Osaka International Cancer Institute / Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Miyata, Hiroshi Department of Digestive Surgery, Osaka International Cancer Institute
Sugimura, Keijiro Department of Digestive Surgery, Osaka International Cancer Institute
Motoori, Masaaki Department of Surgery, Osaka General Medical Center
Asukai, Kei Department of Digestive Surgery, Osaka International Cancer Institute
Yanagimoto, Yoshitomo Department of Digestive Surgery, Osaka International Cancer Institute
Yamamoto, Kazuyoshi Department of Digestive Surgery, Osaka International Cancer Institute
Akita, Hirofumi Department of Digestive Surgery, Osaka International Cancer Institute
Nishimura, Junichi Department of Digestive Surgery, Osaka International Cancer Institute
Wada, Hiroshi Department of Digestive Surgery, Osaka International Cancer Institute
Takahashi, Hidenori Department of Digestive Surgery, Osaka International Cancer Institute
Yasui, Masayoshi Department of Digestive Surgery, Osaka International Cancer Institute
Omori, Takeshi Department of Digestive Surgery, Osaka International Cancer Institute
Ohue, Masayuki Department of Digestive Surgery, Osaka International Cancer Institute
Fujiwara, Yoshiyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Yano, Masahiko Department of Digestive Surgery, Osaka International Cancer Institute
キーワード
C-reactive protein-to-prealbumin ratio
esophageal cancer
esophagectomy
inflammatory marker
prognosis
抄録
Background: The prognostic value of combination of C-reactive protein and prealbumin (CRP/PAlb) in esophageal cancer remains unclear. Methods: We enrolled 167 esophageal cancer patients who underwent curative esophagectomy. Univariate and multivariate analyses were performed to determine the prognostic significance of various markers, including CRP-to-albumin (CRP/Alb) ratio, modified Glasgow prognostic score, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index. Results: Receiver operating characteristic analysis revealed the optimal cut-off value of each inflammatory factor, and CRP/PAlb ratio had the greatest discriminative power in predicting recurrence-free survival (RFS) among the examined measures (AUC 0.668). The 5-year overall survival and RFS rates were significantly lower in patients with high CRP/PAlb ratio than in those with low CRP/PAlb ratio (P < 0.001, P = 0.001, respectively). In the univariate analysis, RFS was significantly worse in patients with low BMI, T2 or deeper tumor invasion, positive lymph node metastasis, positive venous invasion, high CRP/PAlb ratio, high CRP/Alb ratio, high NLR, and high LMR. Multivariate analysis revealed that CRP/PAlb, but not CRP/Alb, was an independent prognostic factor along with lymph node metastasis. Conclusion: CRP/PAlb ratio was useful for predicting the prognosis of esophageal cancer patients.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
0513-5710
EISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
63
1
開始ページ
8
終了ページ
19
Original Article
発行日
2020-2-20
出版者DOI
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
掲載情報
Tomoyuki Matsunaga, Hiroshi Miyata, Keijiro Sugimura, Masaaki Motoori, Kei Asukai, Yoshitomo Yanagimoto, Kazuyoshi Yamamoto, Hirofumi Akita, Junichi Nishimura, Hiroshi Wada, Hidenori Takahashi, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano, Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer, Yonago Acta Medica, 2020, Volume 63, Issue 1, Pages 8-19, Released February 20, 2020
部局名
医学部・医学系研究科・医学部附属病院
言語
英語