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コラーゲン誘発関節炎ラットにおける腰椎変化の組織学的評価
著者
三原 徳満
キーワード
collagen-induced arthritis rat
lumbar spine
rheumatoid arthritis
抄録
【Background】 To histologically evaluate lumbar involvement in rheumatoid arthritis (RA) by investigating rats with collagen-induced arthritis (CIA) and to assess the potential effects of RA on the discovertebral joints and facet joints.
【Methods】 Seven-month-old female Sprague-Dawley rats were divided into groups with CIA and without CIA (control). All rats were sacrificed at 8 weeks after initial sensitization and the lumbar spine (L5/6) was harvested. Then the lumbar spine block specimens were stained with Villaneuva bone stain and sectioned in the midsagittal plane. The left facet joints were also sectioned in the midaxial plane. Specimens were studied under a microscope and infiltration of inflammatory cells was investigated.
【Results】 In the CIA group, lumbar lesions were observed in 13/18 rats (76%). Lymphocytes infiltrated into the anterior rim of the vertebral bodies only in 2 rats, while lymphocytes infiltrated the facet joints only in 4 rats. Both sites were involved in 7 rats. In addition, osteoclasts invaded the anterior rim of the vertebral bodies and formed cavities that also contained lymphocytes. Formation of pannus was seen in the facet joints in 11/18 rats.
【Conclusion】 In CIA rats, infiltration of inflammatory cells into the anterior rim of the vertebral bodies alone or into the facet joints alone was demonstrated in 2 rats and 4 rats, respectively, while both sites were involved in 7 rats. Therefore, lesions at the anterior rim of the vertebral body did not arise secondary to facet joint involvement, but were caused by CIA along with synovial lesions of the facet joints.
資料タイプ
学位論文(要旨のみのもの含む)
外部リンク
最新掲載誌名
発行日
2018-03-01
著者版フラグ
博士論文全文を含む
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。
掲載情報
This research was published by Yonago Acta Medica: Tokumitsu Mihara, Shinji Tanishima, Atsushi Tanida, Ryota Teshima and Hideki Nagashima. Histological Evaluation of Lumbar Spine Changes in Rats with Collagen-induced Arthritis. Yonago Acta Medica, 2018, 61, pp.66-71
言語
英語
学位論文授与番号
甲第882号
学位授与年月日
2018-03-01
学位名
博士(医学)
学位授与機関
鳥取大学