フルテキストファイル
著者
Colak, Dilek Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research
Mori, Tetsuji Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research 研究者総覧 KAKEN
S. Brill, Monika Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research / Physiological Genomics, University of Munich
Pfeifer, Alexander Institute for Pharmacology and Toxicology, University of Bonn
Falk, Sven Institute of Anatomy, University of Zurich
Deng, Chuxia Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Monteiro, Rui Developmental Biology, Hubrecht Institute
Mummery, Christine Developmental Biology, Hubrecht Institute
Sommer, Lukas Institute of Anatomy, University of Zurich
Götz, Magdalena Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research / Physiological Genomics, University of Munich
キーワード
neural stem cells
Olig2
Dlx2
neurogenesis
oligodendrocytes
transplantation
抄録
In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. Transplantation experiments further verified the cell-autonomous nature of this phenotype. Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis.
出版者
Society for Neuroscience
資料タイプ
学術雑誌論文
外部リンク
ISSN
02706474
書誌ID
AA10620404
掲載誌名
The Journal of Neuroscience
最新掲載誌名
The Journal of Neuroscience
28
2
開始ページ
434
終了ページ
445
Development/Plasticity/Repair
発行日
2008-01-09
出版者DOI
著者版フラグ
出版社版
著作権表記
Copyright © 2008 Society for Neuroscience
掲載情報
Colak, Dilek, et al. "Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells." Journal of Neuroscience 28.2 (2008): 434-446.
部局名
医学部・医学系研究科・医学部附属病院
言語
英語