フルテキストファイル
著者
Gotou, Takahiro Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Kameyama, Katsuro Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences / Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Kobayashi, Ayane Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Okamura, Kayoko Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Ando, Takahiko Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University
Terata, Keiko Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Yamada, Chihiro Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Ohta, Hiroyuki Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Morizane, Ayaka Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University
Hata, Yoshio Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences / Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
visual cortex
geniculocortical axons
dark rearing
ocular dominance
monocular deprivation
amblyopia
抄録
Monocular deprivation (MD) of vision during early postnatal life induces amblyopia, and most neurons in the primary visual cortex lose their responses to the closed eye. Anatomically, the somata of neurons in the closed-eye recipient layer of the lateral geniculate nucleus (LGN) shrink and their axons projecting to the visual cortex retract. Although it has been difficult to restore visual acuity after maturation, recent studies in rodents and cats showed that a period of exposure to complete darkness could promote recovery from amblyopia induced by prior MD. However, in cats, which have an organization of central visual pathways similar to humans, the effect of dark rearing only improves monocular vision and does not restore binocular depth perception. To determine whether dark rearing can completely restore the visual pathway, we examined its effect on the three major concomitants of MD in individual visual neurons, eye preference of visual cortical neurons and soma size and axon morphology of LGN neurons. Dark rearing improved the recovery of visual cortical responses to the closed eye compared with the recovery under binocular conditions. However, geniculocortical axons serving the closed eye remained retracted after dark rearing, whereas reopening the closed eye restored the soma size of LGN neurons. These results indicate that dark rearing incompletely restores the visual pathway, and thus exerts a limited restorative effect on visual function.
出版者
Frontiers Media
資料タイプ
学術雑誌論文
外部リンク
EISSN
16625110
掲載誌名
FRONTIERS IN NEURAL CIRCUITS
最新掲載誌名
FRONTIERS IN NEURAL CIRCUITS
15
発行日
2021-04-16
出版者DOI
著者版フラグ
出版社版
著作権表記
Copyright © 2021 Gotou, Kameyama, Kobayashi, Okamura, Ando, Terata, Yamada, Ohta, Morizane and Hata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
掲載情報
Gotou Takahiro, Kameyama Katsuro, Kobayashi Ayane, et al. Dark Rearing Promotes the Recovery of Visual Cortical Responses but Not the Morphology of Geniculocortical Axons in Amblyopic Cat. FRONTIERS IN NEURAL CIRCUITS. 2021. 15. doi:10.3389/fncir.2021.637638
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000645540400001