フルテキストファイル | |
著者 |
Gotou, Takahiro
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Kameyama, Katsuro
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences / Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University
研究者総覧
KAKEN
Kobayashi, Ayane
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Okamura, Kayoko
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Ando, Takahiko
Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University
Terata, Keiko
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Yamada, Chihiro
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Ohta, Hiroyuki
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences
Morizane, Ayaka
Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University
Hata, Yoshio
Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences / Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University
研究者総覧
KAKEN
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キーワード | visual cortex
geniculocortical axons
dark rearing
ocular dominance
monocular deprivation
amblyopia
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抄録 | Monocular deprivation (MD) of vision during early postnatal life induces amblyopia, and most neurons in the primary visual cortex lose their responses to the closed eye. Anatomically, the somata of neurons in the closed-eye recipient layer of the lateral geniculate nucleus (LGN) shrink and their axons projecting to the visual cortex retract. Although it has been difficult to restore visual acuity after maturation, recent studies in rodents and cats showed that a period of exposure to complete darkness could promote recovery from amblyopia induced by prior MD. However, in cats, which have an organization of central visual pathways similar to humans, the effect of dark rearing only improves monocular vision and does not restore binocular depth perception. To determine whether dark rearing can completely restore the visual pathway, we examined its effect on the three major concomitants of MD in individual visual neurons, eye preference of visual cortical neurons and soma size and axon morphology of LGN neurons. Dark rearing improved the recovery of visual cortical responses to the closed eye compared with the recovery under binocular conditions. However, geniculocortical axons serving the closed eye remained retracted after dark rearing, whereas reopening the closed eye restored the soma size of LGN neurons. These results indicate that dark rearing incompletely restores the visual pathway, and thus exerts a limited restorative effect on visual function.
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出版者 | Frontiers Media
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資料タイプ |
学術雑誌論文
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外部リンク | |
EISSN | 16625110
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掲載誌名 | FRONTIERS IN NEURAL CIRCUITS
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最新掲載誌名 |
FRONTIERS IN NEURAL CIRCUITS
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巻 | 15
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発行日 | 2021-04-16
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出版者DOI | |
著者版フラグ |
出版社版
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著作権表記 | Copyright © 2021 Gotou, Kameyama, Kobayashi, Okamura, Ando, Terata, Yamada, Ohta, Morizane and Hata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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掲載情報 | Gotou Takahiro, Kameyama Katsuro, Kobayashi Ayane, et al. Dark Rearing Promotes the Recovery of Visual Cortical Responses but Not the Morphology of Geniculocortical Axons in Amblyopic Cat. FRONTIERS IN NEURAL CIRCUITS. 2021. 15. doi:10.3389/fncir.2021.637638
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部局名 |
医学部・医学系研究科・医学部附属病院
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言語 |
英語
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Web of Science Key ut | WOS:000645540400001
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