| フルテキストファイル | |
| 著者 |
Ezomo Ojeiru F
Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
研究者総覧
Takahashi Kazuya
Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
Horie Yuki
Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
Mustak Mohammed S
Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
Meshitsuka Shunsuke
Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
KAKEN
|
| キーワード | circular dichroism
GATA-2
transcription factor
Zn finger
|
| 抄録 | The C-terminal zinc finger domain of GATA-2 transcription factor from Rattus norvegicus has been expressed and purified to elucidate its secondary structure using circular dichroism spectroscopy. Circular dichroism spectra showed that native GATA-2 C-terminal domain of (Cys)4 type zinc finger has 12% α-helix, 36% β-sheet and 52% random coil content. The estimated structure was compared with predicted structures by sequence based prediction software SOPMA and found to be similar. Furthermore, the effect of pH on the secondary structure of GATA-2 C-finger was examined. This study provides an insight into the understanding of the structure and function of transcription factor GATA-2.
|
| 出版者 | Tottori University Faculty of Medicine
|
| 資料タイプ |
学術雑誌論文
|
| ISSN | 1346-8049
|
| 書誌ID | AA00892882
|
| 掲載誌名 | Yonago Acta medica
|
| 最新掲載誌名 |
Yonago Acta medica
|
| 巻 | 53
|
| 号 | 1
|
| 開始ページ | 25
|
| 終了ページ | 28
|
| 発行日 | 2010-03
|
| 著者版フラグ |
出版社版
|
| 著作権表記 | Yonago Acta medica 編集委員会
|
| 掲載情報 | Yonago Acta medica. 2010, 53(1), 25-28
|
| 部局名 |
医学部・医学系研究科・医学部附属病院
|
| 言語 |
英語
|
