フルテキストファイル
著者
Hosoda, Yuzuru Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine / Department of Hematology, Tottori University Hospital 研究者総覧
Hagino, Hiroshi Division of Rehabilitation, Tottori University Hospital 研究者総覧 KAKEN
Hino, Norihiko Department of Hematology, Tottori University Hospital
Motokura, Toru Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine / Department of Hematology, Tottori University Hospital 研究者総覧 KAKEN
キーワード
bendamustine
Evans syndrome
immune thrombocytopenia
splenomegaly
rheumatoid arthritis
抄録
Chemotherapy for lymphoma may be avoided in the presence of coincident cytopenia. In case of immune cytopenia secondary to lymphoma, treatment of cytopenia is the same for primary cases, however, chemotherapy for lymphoma may be effective at the cost of severe hematological toxicity. The present study reports a complex case of thrombocytopenia and direct antiglobulin test‑negative hemolytic anemia, thus mimicking Evans syndrome, secondary to cluster of differentiation 5‑positive B‑cell lymphoma with massive splenomegaly, in a patient suffering from rheumatoid arthritis for two decades. Treatment with prednisolone, high‑dose dexamethasone, eltrombopag and rituximab for cytopenia were not effective. Chemotherapy with bendamustine subsequently resolved the cytopenia, additionally resulting in a complete remission of lymphoma. Thus, bendamustine may have a role in the management of lymphoma complicated with severe cytopenia.
出版者
Spandidos Publications
資料タイプ
学術雑誌論文
外部リンク
ISSN
20499450
EISSN
20499469
掲載誌名
MOLECULAR AND CLINICAL ONCOLOGY
最新掲載誌名
MOLECULAR AND CLINICAL ONCOLOGY
7
5
開始ページ
855
終了ページ
858
発行日
2017-11
出版者DOI
著者版フラグ
出版社版
著作権表記
Copyright © Spandidos Publications 2017
掲載情報
Hosoda Yuzuru, Hagino Hiroshi, Hino Norihiko, et al. Efficacy of bendamustine on thrombocytopenia and hemolytic anemia secondary to CD5-positive B-cell lymphoma with massive splenomegaly in a patient with rheumatoid arthritis. MOLECULAR AND CLINICAL ONCOLOGY. 2017. 7(5). 855-858. doi:10.3892/mco.2017.1425
部局名
医学部・医学系研究科・医学部附属病院
言語
英語
Web of Science Key ut
WOS:000455354600026