フルテキストファイル
著者
Kohama Kiyotaka Second Department of Internal Medicine, Faculty of Medicine, Tottori University
Uemasu Jiro Second Department of Internal Medicine, Faculty of Medicine, Tottori University
Kawasaki Hironaka Second Department of Internal Medicine, Faculty of Medicine, Tottori University
Nanba Eiji Gene Research Center, Tottori University 研究者総覧 KAKEN
Tokumoto Akihide Division of Nephrology, Sanin Rosai Hospital
キーワード
bone mineral density
hemodialysis
renal osteodystrophy
vitamin D receptor gene polymorphismz
抄録
We examined the possible involvement of vitamin D receptor (VDR) gene polymorphisms in patients on maintenance hemodialysis and further investigated the relation between VDR genotypes and bone histology. Two hundred and nine patients undergoing regular hemodialysis (male/female ratio, 124/85) were included in this study. DNA was extracted from peripheral blood leukocytes. VDR genotypes were analyzed as restriction fragment length polymorphisms, by using BsmI, ApaI, TaqI and FokI. Lumbar bone mineral density was measured by dual-energy X-ray absorptiometry, and expressed as a Z-score. Serum 1,25(OH)2D3, osteocalcin and ntact-parathyroid hormone (i-PTH) were determined by an immunoradiometric assay. In 97 patients, bone biopsy as performed and the histology was divided into osteitis fibrosa, mild lesion, dynamic bone disease and osteomalacia. Serum levels of osteocalcin, i-PTH and bone mineral density were significantly lower in the presence of B, A, t and f alleles. However, in this study, we did not find any association between bone histology and the four VDR genotypes. We concluded that renal osteodystrophy in dialysis patients was modified by environmental factors such as medication with active vitamin D, age, gender and duration of chronic renal failure, and that the impact of the VDR allelic effect may play a small role in determining on bone histology.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
43
1
開始ページ
27
終了ページ
38
発行日
2000-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2000, 43(1), 27-38
部局名
医学部・医学系研究科・医学部附属病院
言語
英語