フルテキストファイル
著者
Yoshida Haruhiko Department of Pathobiological Science and Technology, Tottori University Faculty of Medicine KAKEN
Watanabe Mari First Department of Pathology, Tottori University Faculty of Medicine
Shomori Kohei First Department of Pathology, Tottori University Faculty of Medicine KAKEN
Ito Hisao First Department of Pathology, Tottori University Faculty of Medicine KAKEN
Minamizaki Takeshi Department of Orthopaedic Surgery, Tottori University Faculty of Medicine
キーワード
apoptosis/immunohistochemistry/leiomyosarcoma/p53 protein
抄録
Leiomyosarcoma (LMS) of soft-tissue origin was studied on the expression and the biological significance of apoptosis in relation to p53 oncoprotein. Immunohistochemical analysis was performed initially on the paraffin-embbeded sections taken from 29 surgical tissues (20 cases) including 9 recurrent/metastatic tumors. The results are as follows: A positive correlation was observed between the p53 indices (PIs) and the proliferative markers designated by Ki-67, PCNA and MCM2, both of which increased significantly in the high-grade malignant LMS much more than in the low-grade one (P < 0.001). Apoptotic cells were detected by the TUNEL method and evaluated as the apoptotic index (AI). A high AI-level was shown in the high-grade malignant LMS, especially in cases of the recurrent/metastatic sites in comparison with the tumors of the primary site (P < 0.05). The AI was statistically higher in the p53-positive cases of high-grade malignant LMS than in the p53-negative cases of low-grade malignant LMS. In conclusion, apoptotic activity paralleled the overexpression of p53 protein along with an increasing grade of malignancy and may be related intimately to the increased malignant potential, especially to recurrence/metastasis.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
44
2
開始ページ
115
終了ページ
123
発行日
2001-07
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2001, 44(2), 115-123
部局名
医学部・医学系研究科・医学部附属病院
言語
英語