フルテキストファイル
著者
Satoh Yukio Department of Biosignaling, Faculty of Medicine, Tottori University
Sairenji Takeshi Department of Biosignaling, Faculty of Medicine, Tottori University
キーワード
EGF receptor
EGF receptor mRNA
mRNA stability
regulation of gene expression
thyroid hormone
抄録
The expression of epidermal growth factor (EGF) receptor mRNA was examined using thyroid hormone L-3,5,3'-triiodothyronine (T3) by Northern blot analysis in rat hepatoma cells. The expression of full-length, but not truncated receptor mRNA was enhanced and destabilized with T3. These results suggest that T3 induces not only the expression of full-length EGF receptor mRNA but also accelerates their rate of turnover. The 3' terminal region of full-length EGF receptor mRNA may have a role in the destabilization of EGF receptor mRNA by T3, because truncated EGF receptor mRNA lacks only the 3' terminal region of full-length EGF receptor mRNA.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
40
3
開始ページ
133
終了ページ
136
発行日
1997-11
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1997, 40(3), 133-136
部局名
医学部・医学系研究科・医学部附属病院
言語
英語