フルテキストファイル
著者
Chikumi, Jun Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University
大石 徹郎 Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University / Department of Obstetrics and Gynecology, Matsue City Hospital 研究者総覧 KAKEN
Nakaso, Takaya Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University
Sawada, Mayumi Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University
Kudoh, Akiko Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University
Komatsu, Hiroaki Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University
佐藤 慎也 Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
谷口 文紀 Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
原田 省 Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
adenomyosis
endometrial cancer
gynecologic oncology
抄録
Uterine adenomyosis is an estrogen-dependent tumor and one of the most common benign diseases in sexually mature women. The frequency of endometrial cancer associated with adenomyosis has been reported to be 18%–66%. On the other hand, endometrial cancer arising in adenomyosis (EC-AIA) is extremely rare. EC-AIA is now considered a different entity from and has a worse prognosis than endometrial cancer with adenomyosis (EC-A). In the present study, we report a case of endometrial cancer with adenomyosis in which endometrial biopsy failed to provide a definitive diagnosis. A 63-year-old female patient presented with endometrial thickening. Endometrial cytology was positive, and magnetic resonance imaging (MRI) showed small lesions suggestive of endometrial cancer with shallow invasion and adenomyosis. However, an endometrial biopsy showed only metaplasia, and careful follow-up was initiated. Subsequent endometrial cytology showed enlarged and round nuclei, uniform chromatin distribution, no thickening of nuclear margins, and abundant cytoplasm appearing in a sheet-like arrangement, suggesting atypical cells of endometrial glands with metaplasia. Three suspicious positive results and one positive result were observed, but repeated biopsies did not lead to the diagnosis of malignancy. The patient underwent diagnostic hysterectomy 19 months after the initial visit. The postoperative histopathological diagnosis was stage IA endometrial cancer (endometrioid carcinoma G1). This case of endometrial cancer associated with adenomyosis was difficult to diagnose. Our findings demonstrate that EC-AIA should be considered even if no lesions were detected by endometrial biopsy.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
05135710
EISSN
13468049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
65
1
開始ページ
106
終了ページ
110
発行日
2022-02-22
出版者DOI
著者版フラグ
出版社版
著作権表記
(C) 2022 Tottori University Medical Press.
掲載情報
Yonago Acta Medica. 2022, 65(1), 106-110. doi10.33160/yam.2022.02.009
部局名
医学部・医学系研究科・医学部附属病院
言語
英語