フルテキストファイル
著者
Leong, Zi Ping The United Graduate School of Veterinary Science, Yamaguchi University
日笠 喜朗 The United Graduate School of Veterinary Science, Yamaguchi University / Joint Department of Veterinary Medicine, Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University 研究者総覧 KAKEN
キーワード
Cardiopulmonary remodeling
Masitinib
Pulmonary arterial hypertension
Right ventricular hypertrophy
Tadalafil
抄録
Targeting vascular remodeling in pulmonary arterial hypertension (PAH) remains a challenge given the lack of potent anti-remodeling abilities of the therapeutic drugs. Although sildenafil has been shown to ameliorate cardiopulmonary remodeling, that of tadalafil is questionable. Masitinib, a tyrosine kinase inhibitor appears safer and more potent than imatinib for treatment of malignancies, but its efficacy on PAH is unknown. Therefore, we investigated the anti-remodeling properties of masitinib (5, 15, 50 mg/kg) and tadalafil (5, 10 mg/kg) using a monocrotaline-induced rat model of PAH. The 14-day treatment with masitinib (15, 50 mg/kg) resulted in significantly decreased right ventricular (RV) systolic pressure (RVSP) and hypertrophy (RVH), and pulmonary vascular remodeling, whereas tadalafil showed weaker anti-remodeling properties. Besides, masitinib significantly blocked the mitogen-associated protein kinase (MAPK) pathway, and reduced phosphodiesterase (PDE)-5 mRNA expression in the lungs. By contrast, tadalafil did not significantly inhibit the MAPK pathway. Further, the 28-day treatment extension revealed that masitinib-treated rats (15 mg/kg) had significantly lower RVSP, and higher heart rate and serum cyclic guanosine monophosphate (cGMP) level, whereas those treated with tadalafil (10 mg/kg) showed insignificantly lower RVSP and higher cGMP level. Moreover, the RVH indices, heart rates, body weight gains, and survival rates of rats in both groups were comparable. Collectively, these results suggest that the treatment with a low-dose masitinib was non-inferior than tadalafil. A lower dose of masitinib may represent a novel approach to target both the cardiopulmonary remodeling and the dysregulated vasoconstriction in PAH.
出版者
Elsevier
資料タイプ
学術雑誌論文
外部リンク
ISSN
15371891
掲載誌名
Vascular Pharmacology
122-123
開始ページ
106599
発行日
2019-12-31
出版者DOI
著者版フラグ
著者版
著作権表記
(C) 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
掲載情報
Leong, Zi Ping. Hikasa, Yoshiaki. Effects of masitinib compared with tadalafil for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats. Vascular Pharmacology. 122-123. 106599. 2019. doi:10.1016/j.vph.2019.106599
部局名
農学部・農学研究科
言語
英語
pii
S1537-1891(19)30119-3