フルテキストファイル
著者
Kioke, Taro Department of Anatomy and Cell ScienceKansai Medical University
Wakabayashi, Taketoshi Department of Anatomy and Cell ScienceKansai Medical University
Mori, Tetsuji Department of Anatomy and Cell ScienceKansai Medical University 研究者総覧 KAKEN
Takamori, Yasuharu Department of Anatomy and Cell ScienceKansai Medical University
Hirahara, Yukie Department of Anatomy and Cell ScienceKansai Medical University
Yamada, Hisao Department of Anatomy and Cell ScienceKansai Medical University
キーワード
Sox2
Peripheral nervous system
Satellite glial cell
Schwann cell
Immunohistochemistry
Rat
抄録
Sex-determining region Y (SRY)-box 2 (Sox2) is a member of the Sox family transcription factors. In the central nervous system, Sox2 is expressed in neural stem cells from neurogenic regions, and regulates stem cell proliferation and differentiation. In the peripheral nervous system, Sox2 is found only in the immature and dedifferentiated Schwann cells, and is involved in myelination inhibition or N-cadherin redistribution. In the present immunohistochemical study, we found that Sox2 is also expressed in other cells of the adult rat peripheral nervous system. Nuclear Sox2 was observed in all satellite glial cells, non-myelinating Schwann cells, and the majority of terminal Schwann cells that form lamellar corpuscles and longitudinal lanceolate endings. Sox2 was not found in myelinating Schwann cells and terminal Schwann cells of subepidermal free nerve endings. Satellite glial cells exhibit strong Sox2 immunoreactivity, whereas non-myelinating Schwann cells show weak immunoreactivity. RT-PCR confirmed the presence of Sox2 mRNA, indicating that the cells are likely Sox2 expressors. Our findings suggest that the role of Sox2 in the peripheral nervous system may be cell-type-dependent.
出版者
Springer Berlin Heidelberg
資料タイプ
学術雑誌論文
外部リンク
ISSN
09486143
書誌ID
AA11033302
掲載誌名
Histochemistry and cell biology
141
3
開始ページ
301
終了ページ
309
Original Paper
発行日
2013-10-31
出版者DOI
著者版フラグ
著者版
著作権表記
© Springer-Verlag Berlin Heidelberg 2013
掲載情報
This is a post-peer-review, pre-copyedit version of an article published in [ Kioke, T., Wakabayashi, T., Mori, T. et al. Histochem Cell Biol (2014) 141: 301. https://doi.org/10.1007/s00418-013-1158-x ]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00418-013-1158-x
部局名
医学部・医学系研究科・医学部附属病院
言語
英語