フルテキストファイル
著者
Izawa Yukihiro Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine. Clinic of Rehabilitation, Okayama Rehabilitation Hospital. Clinic of Rehabilitation, Hakuai Hospital
Urakami Katsuya Depart-ment of Biological Regulation, School of Health Science, Tottori University Faculty of Medicine. Clinic of Neurology, Shinsei Hospital 研究者総覧 KAKEN
Kojima Tomoyuki Ichikawa Con-sultancy for Higher Brain Dysfunction. Sendai Medical and Welfare Vocational College
Ohama Eisaku Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine.
キーワード
Alzheimer’s disease
Digit Symbol
Pairing; screening test for dementia
Wechsler Adult Intelligence Scale
抄録
We examined Alzheimer’s disease (AD) patients using a Japanese version of the Wechsler Adult Intelligence Scale, 3rd Edition (JWAIS-III) to clarify i) the significance of expansion of the indicated age range, ii) the characteristics of cognitive impairment in AD patients and iii) the efficacy of th neuropsychological assessment for the early detection of AD using the Digit Symbol subtest, which involves attention and episodic memory, and the Pairing supplementa-ry test, which relates to digit symbol-incidental learning. The JWAIS-III was given to 43 AD patients (12 males and 31 females; mean age, 80.9 ± 6.3 years, who fulfilled the diagnostic cri-teria for AD on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association. Severity of dementia of the patients was classified according to Functional Assessment Staging (F) as follows: 9 patients in F3 (borderline), 15 in F4 (mild AD), 12 in F5 (moderate AD), 7 in F6 (somewhat severe AD) and none in F7 (severe AD). i) Mean intelligence quotients (IQs) were: Full Scale IQ 84.3 ± 14.0, Verbal IQ 84.6 ± 12.5 and Performance IQ 86.9 ± 15.5. Comparison of IQs and subtest scores of the patients aged 75 years or older assessed by standard scores for 70 to 74 years of age, which is the upper limit of the indicated age range on the WAIS-R (the previous version of the WAIS-III), with those assessed by the standard scores for the appropriate age revealed that the former were significantly lower in IQ and all subtest scores. ii) Significant differ-ences were noted among the severities of dementia in the scores of 7 subtests for Similarities, Comprehension, Arithmetic, Digit Span, Letter-Number Sequencing, Digit Symbol and Sym-bol Search. iii) When both the Digit Symbol subtest scores of 7 points or more and the Digit Sumbol-Pairing supplementary test scores exceeding 10% of the cumulative percentile were regarded as normal, 11 of 15 (73.3%) patients in F4 (mild AD) could be detected. These find-ings suggest that i) expansion of the indicated age range in the WAIS-III allows a more valid assessment of cognitive function in AD patients, ii) a marked decline in abstract thinking and verbal problem-solving ability and relative preservation of Perceptual organization are char-acteristics of cognitive impairment in AD patients and iii) a combination of the Digit Symbol subtest with the Pairing supplementary test is useful for the early detection of AD.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
52
1
開始ページ
10
終了ページ
20
発行日
2009-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2009, 52(1), 10-20
部局名
医学部・医学系研究科・医学部附属病院
言語
英語