フルテキストファイル
著者
Kishi, Masafumi Division of Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Wada-isoe, Kenji Division of Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Hanajima, Ritsuko Division of Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Nakashima, Kenji National Hospital Organization Matsue Medical Center KAKEN
キーワード
cerebral white matter lesions
exercise habits
sleeping disorder
subjective motor symptoms
抄録
Background: Mild parkinsonian signs are important clinical symptoms related to the decline of motor and cognitive functions. We aimed to identify predictors for the incidence of mild parkinsonian signs in older Japanese by conducting an 8-year longitudinal community-based cohort study.

Methods: Participants aged 65 years or older, living in Ama-cho, a rural island town in western Japan, underwent a baseline assessment of motor function, cognitive function, depression score, the Pittsburgh Sleep Quality Index (PSQI), the Tanner questionnaire, and cerebral white matter lesions on brain magnetic resonance imaging from 2008 to 2010, and then underwent a follow-up neurological examination from 2016 to 2017. Mild parkinsonian signs were defined according to a modified Unified Parkinson’s Disease Rating Scale score.

Results: Of the 316 participants without mild parkinsonian signs at baseline, 94 presented with incident mild parkinsonian signs at follow-up. In addition to an absence of exercise habits, a higher score on the Tanner questionnaire, PSQI, and deep white-matter hyperintensity Fazekas scores were significant independent predictors for incidence of mild parkinsonian signs.

Conclusion: We suggest multiple factors related to incidence of mild parkinsonian signs. Vascular lesions and sleep disorders are associated with a pathogenesis of mild parkinsonian signs, the Tanner questionnaire is useful for early detection of subclinical mild parkinsonian signs, and exercise has a possibility of being associated with preventing onset of mild parkinsonian signs.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
05135710
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
63
1
開始ページ
1
終了ページ
7
Original Article
発行日
2020-02-20
出版者DOI
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
掲載情報
Masafumi Kishi, Kenji Wada-isoe, Ritsuko Hanajima, Kenji Nakashima, Predictors for Incident Mild Parkinsonian Signs in Older Japanese, Yonago Acta Medica, 2020, Volume 63, Issue 1, Pages 1-7
部局名
医学部・医学系研究科・医学部附属病院
言語
英語