フルテキストファイル
著者
Hatsuzawa, Kiyotaka Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Sakurai, Chiye Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
キーワード
MAP1LC3A
membrane fusion
phagocytosis
SNAP23 protein
SNARE proteins
抄録
Synaptosomal associated protein of 23 kDa (SNAP23), a plasma membrane-localized soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE), is a ubiquitously expressed protein that is generally involved in fusion of the plasma membrane and secretory or endosomal recycling vesicles during several types of exocytosis. SNAP23 is expressed in phagocytes, such as neutrophils, macrophages, and dendritic cells, and functions in both exocytosis and phagocytosis. This review focuses on the function of SNAP23 in immunoglobulin G Fc receptor-mediated phagocytosis by macrophages. SNAP23 and its partner SNAREs mediate fusion of the plasma membrane with intracellular organelles or vesicles to form phagosomes as well as the fusion of phagosomes with endosomes or lysosomes to induce phagosome maturation, characterized by reactive oxygen species production and acidification. During these processes, SNAP23 function is regulated by phosphorylation. In addition, microtubule-associated protein 1A/1B light chain 3 (LC3)-associated phagocytosis, which tightly promotes or suppresses phagosome maturation depending on the foreign target, requires SNAP23 function. SNAP23 that is enriched on the phagosome membrane during LC3-associated phagocytosis may be phosphorylated or dephosphorylated, thereby enhancing or inhibiting subsequent phagosome maturation, respectively. These findings have increased our understanding of the SNAP23-associated membrane trafficking mechanism in phagocytes, which has important implications for microbial pathogenesis and innate and adaptive immune responses.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN
0513-5710
EISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
63
3
開始ページ
135
終了ページ
145
Review Articles: Special Contribution
発行日
2020-8-20
出版者DOI
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
掲載情報
Hatsuzawa Kiyotaka, Sakurai Chiye. Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation. Yonago Acta Medica. 2020, 63(3). 135-145. doi: 10.33160/yam.2020.08.001.
部局名
医学部・医学系研究科・医学部附属病院
言語
英語